Why the study?
Does individualized heparin dosing based on ACT and HC profiles accurately predict actual ACT compared to standard treatment in patients undergoing hemodialysis?
Population
17 patients undergoing hemodialysis
Comparison
Individualized dose of heparin based on… vs Standard treatment of heparin
Design
RCT, Randomized to receive standard treatment or an individualized dose in the…
Follow-up
4 weeks
Authors
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Supports individualized heparin dosing for target ACT in hemodialysis; extends pharmacokinetic modeling to routine dialysis anticoagulation.
Does individualized heparin dosing based on ACT and HC profiles accurately predict actual ACT compared to standard treatment in patients undergoing hemodialysis?
Individualized heparin dosing based on pharmacokinetic and pharmacodynamic profiles can accurately predict activated coagulation times during hemodialysis despite significant interpatient variability.
Kandrotas et al. (1990) studied this question.
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