What question did this study set out to answer?

Determine whether pituitary homografts in the hypophysiotrophic area require direct connections to the median eminence to maintain resting and stress-induced ACTH and corticosterone secretion.

March 20, 2008Neuroendocrinology

Further Studies on ACTH Secretion from Pituitary Grafts in the Hypophysiotrophic Area

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Authors

VCV. CsernusSemmelweis University ILIstvàn LengváriUniversity of Pecs BHBéla HalászSemmelweis University

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Implication

Experimental study reveals stress-induced corticosterone release requires median eminence contact with pituitary grafts in hypophysectomized rats, suggesting the median eminence produces CRF.

Key Points

Determine whether pituitary homografts in the hypophysiotrophic area require direct connections to the median eminence to maintain resting and stress-induced ACTH and corticosterone secretion.
Measured resting and stress-induced plasma corticosterone concentrations fluorimetrically in adult male hypophysectomized rats bearing hypothalamic pituitary homografts.
Categorized endocrine responses based on whether grafts were located in the medial basal hypothalamus (hypophysiotrophic area) and whether anatomical connections to the median eminence were present.
Maintenance of resting corticosterone levels and significant post-stress elevations occurred exclusively in rats with grafts in the medial basal hypothalamus connected directly to the median eminence.
Grafts placed in the hypophysiotrophic area lacking median eminence connections showed depressed resting corticosterone concentrations and completely failed to elevate hormone levels following stress.

Cite This Study

Csernus et al. (2008) studied this question.

synapsesocial.com/papers/6a6fe1ff75498292b7094230 https://doi.org/10.1159/000122337

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Implication

Experimental study reveals stress-induced corticosterone release requires median eminence contact with pituitary grafts in hypophysectomized rats, suggesting the median eminence produces CRF.

Further Studies on ACTH Secretion from Pituitary Grafts in the Hypophysiotrophic Area

Discussion

Member takes

Implication

Key Points

Cite This Study

Further Studies on ACTH Secretion from Pituitary Grafts in the Hypophysiotrophic Area

Discussion

Member takes

Implication

Key Points

Cite This Study

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