Why the study?
Does altering afterload or heart rate affect NAD(P)H redox state in isolated rabbit hearts?
Population
Isolated, normothermic, working rabbit hearts
Comparison
Alterations in work under conditions of limited… vs Baseline conditions prior to altering afterload…
Design
Preclinical
Authors
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Isolated heart data warrant no clinical changes to afterload or rate management; leaves open NAD(P)H redox regulation of respiration in vivo.
Does altering afterload or heart rate affect NAD(P)H redox state in isolated rabbit hearts?
NAD(P)H redox state is not the primary stimulus for increased myocardial respiration secondary to tachycardia or afterload, as it remains relatively stable despite increased rates of cardiac work.
Heineman et al. (1993) studied this question.
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