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May 30, 2017Proceedings of the National Academy of SciencesOpen Access

Viral and cellular mRNA-specific activators harness PABP and eIF4G to promote translation initiation downstream of cap binding

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Authors

RSRichard SmithUniversity of South Florida RARoss C. AndersonUniversity of Pretoria OLOsmany LarraldeScottish National Blood Transfusion Service

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Implication

Reveals mechanisms of mRNA-specific translational activation; extends molecular models of gene expression control.

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Cite This Study

Smith et al. (2017) studied this question.

synapsesocial.com/papers/6a6fe6d7660549caf2c470dc https://doi.org/10.1073/pnas.1610417114

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Also Consider

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1Poly(A)-binding protein (PABP): a common viral target2010 · 94 citations
2The requirement for eukaryotic initiation factor 4A (eIF4A) in translation is in direct proportion to the degree of mRNA 5′ secondary structure2001 · 478 citations
3A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initation of hepatitis C and classical swine fever virus RNAs1998 · 735 citations
4Direct Stimulation of Translation by the Multifunctional Herpesvirus ICP27 Protein2006 · 61 citations
5The stem–loop binding protein stimulates histone translation at an early step in the initiation pathway2005 · 68 citations