Population
RNAs harboring internal ribosome entry sites from three diverse viruses: encephalomyocarditis virus…
Comparison
Poly(A) tract and PABP (or PABP inhibitor Paip2) vs RNAs without poly tract or without PABP inhibition
Design
Preclinical
Authors
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May inform antiviral RNA targeting; leaves open PABP roles beyond initiation in plus-strand viruses.
The study demonstrates mechanistic differences between viral IRES elements, suggesting modulating roles for PABP and the poly(A) tail at multiple phases of translation.
Bradrick et al. (2007) studied this question.
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