February 9, 2017Journal of VirologyOpen Access

A Sequence-Independent, Unstructured Internal Ribosome Entry Site Is Responsible for Internal Expression of the Coat Protein of Turnip Crinkle Virus

View Full Paper

Ask AI

Bookmark

Structured PICO

Population

Turnip crinkle virus (TCV) genomic RNA (gRNA) and reporter constructs evaluated in vitro and in vivo

Intervention

Unstructured internal ribosome entry site (IRES) sequence of ~84 nucleotides upstream of the TCV coat protein (CP) open reading frame

Outcome

Internal expression of the coat protein (CP) from the genomic RNAsurrogate

An unstructured IRES in Turnip crinkle virus promotes cap-independent translation of the viral coat protein, highlighting a strategy that may be shared with cellular mRNA IRES.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Challenges assumption of structured RNA in viral IRES; extends cap-independent translation models to unstructured sequences.

Cite This Study

May et al. (2017) studied this question.

synapsesocial.com/papers/6a6fe6d7660549caf2c470dd https://doi.org/10.1128/jvi.02421-16

View Full Paper

Ask AI

Bookmark

A Sequence-Independent, Unstructured Internal Ribosome Entry Site Is Responsible for Internal Expression of the Coat Protein of Turnip Crinkle Virus

Structured PICO

Discussion

Implication

Cite This Study

A Sequence-Independent, Unstructured Internal Ribosome Entry Site Is Responsible for Internal Expression of the Coat Protein of Turnip Crinkle Virus

Structured PICO

Discussion

Implication

Cite This Study

Keep reading

Keep reading