Key result
The IRES5'UTR of the Cricket paralysis virus recruits eukaryotic initiation factor 3 and contains an essential pseudoknot structure for proper folding and direct ribosome recruitment.
The IRES5'UTR of the cricket paralysis virus is a type III IRES containing an essential pseudoknot structure for ribosome recruitment.
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No immediate clinical implications; leaves open IRES engineering for cardiovascular gene therapy research.
Gross et al. (2017) studied Cricket paralysis virus (CrPV). IRES5'UTR was evaluated on Translation initiation mechanism and secondary structure. The IRES5'UTR of the Cricket paralysis virus recruits eukaryotic initiation factor 3 and contains an essential pseudoknot structure for proper folding and direct ribosome recruitment.
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