What question did this study set out to answer?

This study examines whether different left ventricular stimulation sites affect diastolic function during cardiac resynchronization therapy.

January 1, 2007Pacing and Clinical Electrophysiology

Effects of Stimulation Site on Diastolic Function in Cardiac Resynchronization Therapy

View Full Paper

Ask AI

Bookmark

Why the study?

Does the left ventricular stimulation site in cardiac resynchronization therapy affect diastolic and systolic function in patients with severe heart failure?

Key Points

This study examines whether different left ventricular stimulation sites affect diastolic function during cardiac resynchronization therapy.
21 patients with heart failure in NYHA class ≥ III and LV ejection fraction < 0.30 were studied.
CRT leads were placed in various heart locations, and stimulation was applied from postero-lateral and antero-lateral walls.
LV systolic and diastolic functions were measured using a conductance catheter.
Diastolic responders decreased from 29% to 10% of patients, while systolic responders decreased from 76% to 48% between best and worst lead positions.
Diastolic function improvement was -14%, compared to +28% for systolic function (P < 0.05).
45% of patients were both systolic and diastolic responders, while 38% had opposite responses.

Structured PICO

Does the left ventricular stimulation site in cardiac resynchronization therapy affect diastolic and systolic function in patients with severe heart failure?

Population

21 patients with heart failure, NYHA functional class >= III, LV ejection fraction < 0.30, and QRS duration > 130 ms

Intervention

Cardiac resynchronization therapy (CRT) with left ventricular stimulation from the postero-lateral and antero-lateral wall

Comparator

Baseline (pre-CRT) and comparison between best and worst LV lead positions

Outcome

Changes in systolic function (>10% change in dP/dt(max)) and diastolic function (<10% change in tau) measured by LV conductance cathetersurrogate

Both systolic and diastolic functional improvements during CRT are highly dependent on the LV stimulation site, though diastolic function is less influenced overall and often shows discordant responses compared to systolic function.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

LV lead position was associated with variable CRT response in severe HF; hypothesis-generating for site-specific diastolic optimization in prospective trials.

Cite This Study

Cock et al. (2007) studied this question.

synapsesocial.com/papers/6a6fe73cac440176ef288dc7 https://doi.org/10.1111/j.1540-8159.2007.00601.x

Topics

Heart failure HFrEF treatment

View Full Paper

Ask AI

Bookmark

Implication

LV lead position was associated with variable CRT response in severe HF; hypothesis-generating for site-specific diastolic optimization in prospective trials.

Effects of Stimulation Site on Diastolic Function in Cardiac Resynchronization Therapy

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Effects of Stimulation Site on Diastolic Function in Cardiac Resynchronization Therapy

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider