Why the study?
Does genetic ablation of PARP-1 protect against ischemic renal injury in mice?
Population
Mice subjected to 37 min of bilateral renal pedicle occlusion (ischemic renal injury model)
Comparison
Genetic ablation of PARP-1 (PARP-/- mice) vs Wild-type counterparts (PARP+/+ mice)
Design
Preclinical
Follow-up
24 hours
Authors
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PARP-1 ablation protects against murine ischemic renal injury; leaves open translation to human AKI therapies.
Does genetic ablation of PARP-1 protect against ischemic renal injury in mice?
Genetic ablation of PARP-1 protects against ischemic renal injury in mice by preserving ATP levels and attenuating the inflammatory response.
Zheng et al. (2004) studied this question.
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