Why the study?
Are plasma betathromboglobulin and serum fragment E levels associated with stroke progression in patients with acute partial stroke?
Are plasma betathromboglobulin and serum fragment E levels associated with stroke progression in patients with acute partial stroke?
Elevated serum fragment E, but not plasma betathromboglobulin, is associated with stroke progression, suggesting fibrin formation may be more important than platelet activation in this process.
Serum FgE was associated with progression in acute partial stroke; hypothesis-generating for fibrin over platelet pathways, needs prospective validation.
Plasma betathromboglobulin (BTG) and serum fragment E (FgE) were measured serially by radioimmunoassay for 7 d in 67 patients admitted with acute partial stroke. Twelve patients progressed within 7 d of admission. Plasma BTG was not different from normal in patients with acute partial stroke and did not increase significantly with stroke progression. Serum FgE was elevated in patients with acute partial stroke compared with normal values, and was significantly higher in patients who progressed compared with those who remained stable. The results indicate that fibrin formation may be more important in the process of stroke progression than activation of platelets.
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Boer et al. (1982) studied this question.
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