February 1, 1995Hypertension
Carotid Artery Mechanical Properties of Dahl Salt-Sensitive Rats
Why the study?
Does indapamide improve carotid artery mechanical properties and prevent hypertension in Dahl salt-sensitive rats?
Population
Anesthetized Dahl salt-sensitive and salt-resistant rats fed either a low or high NaCl diet for 5 weeks
Comparison
Indapamide 3 mg/kg per day orally for 5 weeks vs No indapamide treatment
Design
Preclinical
Follow-up
5 weeks
Authors
Discussion
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Implication
Preclinical only in salt-sensitive rats; leaves open any role for indapamide in human hypertension or arterial compliance.
Structured PICO
Does indapamide improve carotid artery mechanical properties and prevent hypertension in Dahl salt-sensitive rats?
P
Population
Anesthetized Dahl salt-sensitive and salt-resistant rats fed either a low (0.4%) or high (7%) NaCl diet for 5 weeks
I
Intervention
Indapamide 3 mg/kg per day orally for 5 weeks
C
Comparator
No indapamide treatment (untreated rats on the same diets)
O
Outcome
Mechanical properties of the carotid artery evaluated by pressure-volume curves in situ in vivo before and after total relaxation of arterial smooth muscle by potassium cyanidesurrogate
Indapamide prevents hypertension and improves carotid artery mechanical properties in Dahl salt-sensitive rats, acting on both arterial structure and function independently of sodium intake.
Cite This Study
Bénétos et al. (1995) studied this question.