Substitution of Expensive Protein Sources by Soybean Meal Supplemented with a β-Mannanase Enzyme Results in Improved General Clinical Health Score during the Post-Weaning Period

oxygen and nitrogen species, bacteriolytic enzymes, antimicrobial peptides and complement proteins These PAMP include complex polysaccharides such as -mannan Therefore, -mannans from feed can create a false signal about the presence of pathogens in the gut, that elicits an unwarranted immune activation The recognition of -mannans elicits a futile immune response that causes energy and nutrients to be wasted Hydrolysis of these -mannans by dietary inclusion of an exogenous -mannanase enzyme can reduce and potentially eliminate their ability to induce FIIR. Supplementation of -mannanase to low-and high-mannan diets has the potential to improve the performance of growing pigs Moreover, ingredients with high -mannan content like palm kernel meal (PKM) or copra meal may partially replace SBM without reducing pig performance if -mannanase is supplemented to the diet Some researchers have suggested that the improved pig performance following -mannanase supplementation to corn-SBM-PKM diets might be due to increased ileal digestibility of different amino acids Others concluded that -mannanase improved growth performance in both weanling and growing-finishing pigs on corn-SBM diets