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November 1, 1993AJP Heart and Circulatory Physiology

Analysis of shear stress and hemodynamic factors in a model of coronary artery stenosis and thrombosis

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Population

18 animals using the Folts model of coronary thrombosis

Design

Preclinical

Authors

JSJohn StronyUniversity Hospitals of ClevelandABA.J. BeaudoinUniversity of Illinois Urbana-ChampaignDBDominik BrandsHunter Holmes McGuire VA Medical Center

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Overview

Caution against clinical extrapolation from this animal model; extends mechanistic insights into stenosis geometry and thrombosis but leaves translation open.

Structured PICO

P
Population
18 animals using the Folts model of coronary thrombosis
I
Intervention
Creation of coronary artery stenosis
O
Outcome
Morphology, histology, and hemodynamic properties of the stenosed vessel (including shear stress and thrombus formation)surrogate

The geometry of the stenosis inflow region is a critical determinant of shear stress and subsequent platelet activation and thrombus formation in coronary arteries.

Cite This Study

Strony et al. (1993) studied this question.

synapsesocial.com/papers/6a6fec5cac440176ef289355https://doi.org/10.1152/ajpheart.1993.265.5.h1787
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