Why the study?
How do patient-related factors such as renal function affect the pharmacokinetics of enoxaparin in patients with acute coronary syndromes?
Population
60 patients with acute coronary syndromes, mean age 74 +/- 10 years, 60% men, body weight 72 +/- 15 kg…
Design
Cohort
Authors
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Supports renal- and sex-adjusted enoxaparin dosing considerations in ACS; leaves open need for prospective validation before practice change.
How do patient-related factors such as renal function affect the pharmacokinetics of enoxaparin in patients with acute coronary syndromes?
In patients with decreased renal function, enoxaparin doses should be adjusted based on body weight, serum creatinine, and gender to avoid excessive anticoagulation.
Hulot et al. (2004) studied this question.
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