Relationship of Ultrasonic Spectral Parameters to Features of Tissue Microstructure

Absfract-&mlytical studies have been conducted to investigate the importance of specific tissue features in determining ultrasonic spectral “signatures” that have proven to be diagnostically useful. Three models of tissue microstructure were considered, and calibrated power spectra were computed for a series of scatterer sizes, concentrations, and acoustic impedances. General results were obtained, then specific parameters were employed to simulate studies of the eye and liver. These results were compared to clinical data-base information, and excellent correspondence was found. Studies using acoustic microscopy, test objects, and clinical data are continuing to refine the analytical model. I. INTRODUCTION U