Why the study?
Does the rate of Interleukin-2 administration modulate the onset of multiple-system organ edema and inflammatory mediators in anesthetized rats?
Population
Anesthetized rats (n=33)
Comparison
Recombinant human IL-2 administered… vs Vehicle-infused controls
Design
Preclinical
Follow-up
6 hours
Authors
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Infusion rate may modulate IL-2 toxicity in rats; hypothesis-generating for human dosing strategies.
Does the rate of Interleukin-2 administration modulate the onset of multiple-system organ edema and inflammatory mediators in anesthetized rats?
Constant infusion, but not rapid bolus administration, of high-dose IL-2 produces multiple-system organ edema and microvascular permeability in rats, potentially explaining early toxicity in cancer patients.
Welbourn et al. (1990) studied this question.
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