December 1, 2003AJP Heart and Circulatory Physiology
Oral antioxidant therapy improves endothelial function in Type 1 but not Type 2 diabetes mellitus
Why the study?
Does oral vitamin C and vitamin E improve endothelium-dependent vasodilation in patients with Type 1 and Type 2 diabetes?
Population
94 subjects including 49 diabetic subjects (26 Type 1 and 23 Type 2) and 45 matched healthy control subjects
Comparison
Oral vitamin C and vitamin E daily for 6 months vs Matching placebo for 6 months
Design
RCT, randomized
Follow-up
6 months
Authors
Discussion
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Member takes
Implication
Antioxidants may improve endothelial function in Type 1 diabetes; challenges uniform benefit across diabetes types.
Structured PICO
Does oral vitamin C and vitamin E improve endothelium-dependent vasodilation in patients with Type 1 and Type 2 diabetes?
P
Population
94 subjects including 49 diabetic subjects (26 Type 1 and 23 Type 2) and 45 matched healthy control subjects
I
Intervention
Oral vitamin C (1,000 mg) and vitamin E (800 IU) daily for 6 months
C
Comparator
Matching placebo for 6 months
O
Outcome
Brachial artery endothelium-dependent vasodilation (EDV) and endothelium-independent vasodilation (EIV) measured by vascular ultrasonographysurrogate
Long-term oral antioxidant therapy improves endothelial function in patients with Type 1 diabetes but not Type 2 diabetes.
Cite This Study
Beckman et al. (2003) studied this question.