Key result
Novel MR techniques quantify local myocardial extraction efficiency for contrast agents in healthy and diseased tissue.
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We have previously shown that the concentration of Gd-DTPA as a function of time ([Gd-DTPA]t(t)) in the myocardium following an intravenous bolus injection of Gd-DTPA can be modeled using the Modified Kety Equation. Fitting this model to measurements of [Gd-DTPA]t(t) in a region of myocardium would allow the determination of myocardial distribution volume (lambda) and the product of flow (F) and extraction efficiency (E), i.e., FE. Thus, to measure F, E must be known. We describe here techniques developed to measure local values of E in normal and diseased myocardium. These techniques are valid for any inert diffusible MR contrast agent.
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Tong et al. (1993) studied normal and diseased myocardium. Techniques for measuring local myocardial extraction efficiency was evaluated on Measurement of local values of extraction efficiency (E). Techniques were developed for the measurement of local myocardial extraction efficiency for inert diffusible MR contrast agents such as Gd-DTPA in normal and diseased myocardium.
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