June 1, 2010Canadian Journal of Physiology and Pharmacology

Glucose-induced endothelin-1 expression is regulated by ERK5 in the endothelial cells and retina of diabetic ratsThis article is one of a selection of papers published in the two-part special issue entitled 20 Years of Endothelin Research.

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Why the study?

Does ERK5 signaling regulate glucose-induced ET-1 expression in diabetic angiopathy?

Population

1-month STZ-induced diabetic rats and human macro- and microvascular endothelial cells

Comparison

Glucose, constitutively active MEK5, and ERK5… vs Control conditions (implied)

Design

Preclinical

Follow-up

24 hours (in vitro), 1 month (in vivo)

Authors

YWYuexiu WuNew York Hospital Queens BFBiao FengWestern University SCShali ChenWestern University

Discussion

Member takes

Implication

May support ERK5 activation to curb ET-1 in hyperglycemia; leaves open clinical translation in diabetic angiopathy.

Structured PICO

Does ERK5 signaling regulate glucose-induced ET-1 expression in diabetic angiopathy?

Population

1-month STZ-induced diabetic rats and human macro- and microvascular endothelial cells

Intervention

Glucose (25 mmol/L), constitutively active MEK5 (caMEK5), and ERK5 siRNA transfection

Comparator

Control conditions (implied)

Outcome

ET-1 mRNA expression, ERK5 and KLF2 expressionsurrogate

ERK5 signaling regulates glucose-induced ET-1 expression, suggesting the ERK5/ET-1 pathway as a potential therapeutic target for diabetic angiopathy.

Cite This Study

Wu et al. (2010) studied this question.

synapsesocial.com/papers/6a6ff2aa660549caf2c47eaf https://doi.org/10.1139/y10-033

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Glucose-induced endothelin-1 expression is regulated by ERK5 in the endothelial cells and retina of diabetic ratsThis article is one of a selection of papers published in the two-part special issue entitled 20 Years of Endothelin Research.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Glucose-induced endothelin-1 expression is regulated by ERK5 in the endothelial cells and retina of diabetic ratsThis article is one of a selection of papers published in the two-part special issue entitled 20 Years of Endothelin Research.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider