Why the study?
Coexistence of diabetes and hypertension exacerbates cardiovascular morbidity, but the effects of acute glucose exposure on vascular smooth muscle cell protein expression and ERK-related remodeling pathways remained unclear.
Does high glucose exposure alter protein expression and ERK-related signaling in rat aortic smooth muscle cells?
Population
Rat aortic smooth muscle cells isolated from male Wistar rats
Comparison
High glucose (20 mM) vs low glucose (5 mM)
Design
In vitro proteomics study
Follow-up
6 days
Key result
Short-term exposure to high glucose (20 mM) in rat aortic smooth muscle cells significantly upregulated 21 proteins (p<0.05) linked to MAPK/ERK signaling and oxidative stress.
Authors
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Should not change clinical practice; leaves open whether these proteomic shifts drive human diabetic vasculopathy.
Does high glucose exposure alter protein expression and ERK-related signaling in rat aortic smooth muscle cells?
p-value: p=<0.05
Short-term high glucose exposure induces significant proteomic changes in vascular smooth muscle cells, upregulating MAPK/ERK signaling and oxidative stress pathways, which may contribute to vascular remodeling in diabetes.
Aldahhasi et al. (2025) studied High glucose-induced changes in vascular smooth muscle cells. High glucose vs. Low glucose (5 mM) was evaluated on Differentially expressed proteins (DEPs) (p=<0.05). Short-term exposure to high glucose (20 mM) in rat aortic smooth muscle cells significantly upregulated 21 proteins (p<0.05) linked to MAPK/ERK signaling and oxidative stress.