Key result
High glucose exposure in A10 vascular smooth muscle cells enhanced the expression of Gαq/11 and PLCβ proteins and oxidative stress, which were restored to control levels by receptor antagonists.
Why the study?
Does high glucose exposure increase G(alpha)q/11 protein expression and signaling in A10 VSMCs via vasoactive peptides and oxidative stress?
Population
A10 vascular smooth muscle cells (VSMCs)
Comparison
High glucose exposure with or without… vs Control cells
Design
Preclinical
Authors
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High glucose enhances G(alpha)q/11 signaling in vascular smooth muscle cells through increased oxidative stress mediated by endogenous Angiotensin II and Endothelin-1.
Does high glucose exposure increase G(alpha)q/11 protein expression and signaling in A10 VSMCs via vasoactive peptides and oxidative stress?
High glucose enhances G(alpha)q/11 signaling in vascular smooth muscle cells through increased oxidative stress mediated by endogenous Angiotensin II and Endothelin-1.
Descorbeth et al. (2010) studied this question. High glucose vs. Control cells was evaluated on Expression of G(alpha)q, G(alpha)11, PLCbeta-1, and PLCbeta-2 proteins and associated signaling. High glucose exposure in A10 vascular smooth muscle cells enhanced the expression of Gαq/11 and PLCβ proteins and oxidative stress, which were restored to control levels by receptor antagonists.
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