Population
Porcine vascular smooth muscle cells (VSMC)
Comparison
High glucose alone or combined with Angiotensin II vs Normal glucose (5.5 mmol/L)
Design
Preclinical
Follow-up
0.5 to 24 hours
Authors
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High glucose and Angiotensin II synergistically activate MAPKs and AP-1 in vascular smooth muscle cells, suggesting a mechanism for accelerated vascular disease in diabetes.
High glucose and Angiotensin II synergistically activate MAPKs and AP-1 in vascular smooth muscle cells, suggesting a mechanism for accelerated vascular disease in diabetes.
Natarajan et al. (1999) studied this question.