Population
Rat vascular smooth muscle cells
Comparison
High glucose exposure, with various inhibitors vs Normal glucose (approximately 4.1 mmol/L) exposure
Design
Preclinical
Authors
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May explain hyperglycemia-driven vascular Ang II excess; leaves open chymase targeting in human diabetic complications.
High glucose stimulates Angiotensin II production in rat vascular smooth muscle cells by upregulating chymase-dependent generation and decreasing ACE2-mediated degradation, providing a mechanism for diabetes-associated vascular complications.
Lavrentyev et al. (2007) studied this question.
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