October 1, 2007Radiology

Injection of Adeno-associated Viral Vector–Encoding Vascular Endothelial Growth Factor Gene in Infarcted Swine Myocardium: MR Measurements of Left Ventricular Function and Strain

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Why the study?

Does AAV-VEGF gene therapy improve LV function and strain in a swine model of reperfused myocardial infarction?

Population

Swine model of reperfused myocardial infarction (n=12 analyzed; 6 treated, 6 controls)

Comparison

Cardiac-specific adeno-associated viral… vs Control animals

Design

Preclinical

Follow-up

8 weeks

Authors

AJAlexis JacquierAix-Marseille Université CHCharles B. HigginsAmerican College of Cardiology AMAlastair J. MartinCardiac Imaging

Discussion

Member takes

Implication

Preserves LVEF in swine reperfused MI; leaves open translation of AAV-VEGF gene therapy to human infarction.

Structured PICO

Does AAV-VEGF gene therapy improve LV function and strain in a swine model of reperfused myocardial infarction?

Population

Swine model of reperfused myocardial infarction (n=12 analyzed; 6 treated, 6 controls)

Intervention

Cardiac-specific adeno-associated viral (AAV) vector-encoding vascular endothelial growth factor gene (VEGF) injected into the periinfarcted and infarcted myocardium 1 hour after reperfusion

Comparator

Control animals

Outcome

Left ventricular (LV) mass and volumes, regional contractility, and circumferential strain measured by MR imaging at 3 days and 8 weekssurrogate

AAV-VEGF gene therapy preserves ejection fraction and improves regional myocardial strain and wall thickening in a swine model of reperfused myocardial infarction.

Cite This Study

Jacquier et al. (2007) studied this question.

synapsesocial.com/papers/6a6ff31b75498292b7095308 https://doi.org/10.1148/radiol.2451061077

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Injection of Adeno-associated Viral Vector–Encoding Vascular Endothelial Growth Factor Gene in Infarcted Swine Myocardium: MR Measurements of Left Ventricular Function and Strain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Injection of Adeno-associated Viral Vector–Encoding Vascular Endothelial Growth Factor Gene in Infarcted Swine Myocardium: MR Measurements of Left Ventricular Function and Strain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider