Key result
A single administration of purified VEGF-A 165 mRNA 1 week post-myocardial infarction improved left ventricular ejection fraction, inotropy, and ventricular compliance at 2 months in mini pigs.
Why the study?
Does purified VEGF-A 165 mRNA improve cardiac function in animal models of myocardial infarction?
Population
Small- and large-animal (mini pigs) permanent occlusion myocardial infarction models
Design
Preclinical
Follow-up
2 months post-treatment
Authors
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Hypothesis-generating for post-MI mRNA therapy; leaves open human translation and long-term outcomes.
Does purified VEGF-A 165 mRNA improve cardiac function in animal models of myocardial infarction?
Intracardiac injection of purified VEGF-A mRNA 1 week post-myocardial infarction improves cardiac function and reduces fibrosis in preclinical swine models.
Carlsson et al. (2018) studied Myocardial infarction. Purified VEGF-A 165 mRNA was evaluated on Cardiac function and myocardial damage. A single administration of purified VEGF-A 165 mRNA 1 week post-myocardial infarction improved left ventricular ejection fraction, inotropy, and ventricular compliance at 2 months in mini pigs.
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