September 1, 1998Stroke

Endothelin B Receptor Antagonists Attenuate Subarachnoid Hemorrhage–Induced Cerebral Vasospasm

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Why the study?

Do ET(B) receptor antagonists prevent and reverse SAH-induced cerebral vasospasm in a rabbit model?

Population

Rabbit double hemorrhage model of subarachnoid hemorrhage (SAH)-induced cerebral vasospasm

Comparison

ET receptor antagonists via intracisternal… vs Untreated SAH-induced spasm

Design

Preclinical

Authors

MZMario ZuccarelloCincinnati Children's Hospital Medical Center RBRiccardo BoccalettiUniversity of Parma ARAlberto RomanoHumanitas University

Discussion

Member takes

Implication

ETB antagonists attenuate experimental vasospasm; hypothesis-generating and should not yet change SAH practice.

Structured PICO

Do ET(B) receptor antagonists prevent and reverse SAH-induced cerebral vasospasm in a rabbit model?

Population

Rabbit double hemorrhage model of subarachnoid hemorrhage (SAH)-induced cerebral vasospasm

Intervention

ET(B) receptor antagonists (BQ788 10 micromol/L or RES-701-1 10 micromol/L) via intracisternal infusion (10 microL/h) or in situ superfusion

Comparator

Untreated SAH-induced spasm

Outcome

Basilar artery spasm (measured by angiography in vivo or direct vessel diameter measurement in situ)surrogate

ET(B) receptor antagonists prevent and reverse SAH-induced cerebral vasospasm in an animal model, providing a rationale for their therapeutic use.

Cite This Study

Zuccarello et al. (1998) studied this question.

synapsesocial.com/papers/6a6ff36ea7fbea1e4407e60a https://doi.org/10.1161/01.str.29.9.1924

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Endothelin B Receptor Antagonists Attenuate Subarachnoid Hemorrhage–Induced Cerebral Vasospasm

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Endothelin B Receptor Antagonists Attenuate Subarachnoid Hemorrhage–Induced Cerebral Vasospasm

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider