Why the study?
Does endothelin-1 play a role in the pathogenesis of cerebral vasospasm following subarachnoid hemorrhage?
Does endothelin-1 play a role in the pathogenesis of cerebral vasospasm following subarachnoid hemorrhage?
The role of endothelin-1 in the pathogenesis of cerebral vasospasm following subarachnoid hemorrhage remains controversial based on existing evidence.
Answers are grounded in this paper and cite their sources.
Endothelin-1's role in post-SAH vasospasm remains inconclusive; leaves open need for definitive trials before targeting it therapeutically.
BACKGROUND: Endothelin-1 is a very powerful endogenous vasoconstrictor substance produced by endothelial cells. Its long-lasting vasoconstrictor and hypertensive action has been well documented in several species, including humans. SUMMARY OF REVIEW: It is generally accepted that endothelin-1 may contribute to the pathogenesis of a number of cardiovascular diseases. In the cerebral vasculature, endothelin-1 has been proposed as a key mediator of cerebral vasospasm following subarachnoid hemorrhage. Availability of endothelin-1 antagonist provided a pharmacologic tool to test the role of endothelin in the development of vasospasm. CONCLUSIONS: This brief review is focused on the controversial results reported by different groups concerning the possible role of endothelin-1 in narrowing of cerebral arteries exposed to autologous blood.
No takes yet. Share an insight, caveat, or question.
Cosentino et al. (1994) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: