Endothelial dysfunction and the potent vasoconstrictor endothelin-1 may play a significant role in the pathogenesis of ischemic stroke and cerebral vasospasm.
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Supports ET-1 targeting research in stroke and vasospasm; leaves open clinical translation pending prospective trials.
Endothelial cells play a key role in the local regulation of the vascular smooth muscle tone by producing and releasing relaxing and contracting factors. Endothelin (ET)-1, one of the most potent endogenous vasoconstrictor substances known, is produced by endothelial cells. In the cerebral vasculature ET-1 is thought to be involved in several pathological conditions, including vasospasm following subarachnoid hemorrhage and stroke. This review contains evidence suggesting that endothelial dysfunction may contribute to the development of ischemic stroke and discusses the current knowledge concerning the role of ET-1 in the pathogenesis of stroke in animal models and in humans.
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Volpe et al. (2000) studied this question.
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