Why the study?
Do subjects with high tolerance to central hypovolemia display higher endogenous oscillations of cerebral blood velocity and arterial pressure at presyncope compared with subjects with low tolerance?
Population
135 subjects exposed to progressive lower body negative pressure until the presence of presyncopal symptoms.
Comparison
High tolerance to central hypovolemia vs Low tolerance to central hypovolemia
Design
Cohort
Authors
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Higher MAP low-frequency oscillations associate with tolerance to central hypovolemia; hypothesis-generating for targeted interventions in hypovolemic states.
Do subjects with high tolerance to central hypovolemia display higher endogenous oscillations of cerebral blood velocity and arterial pressure at presyncope compared with subjects with low tolerance?
High endogenous oscillations of mean arterial pressure and cerebral blood velocity are associated with increased tolerance to central hypovolemia.
Rickards et al. (2011) studied this question.
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