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May 10, 1990New England Journal of MedicineOpen Access

The Effects of Antihypertensive Therapy on Left Ventricular Mass in Elderly Patients

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Why the study?

Does verapamil reduce left ventricular mass compared to atenolol in elderly patients with hypertension?

Population

42 elderly patients with hypertension and mild ventricular hypertrophy

Comparison

Verapamil for six months vs Atenolol for six months

Design

RCT, randomized

Follow-up

six months

Authors

SSSteven P. SchulmanGeneral CardiologyJWJames L. WeissUniversity of Southern CaliforniaLBLewis C. BeckerCardiac Imaging

Discussion

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Implication

Verapamil may be preferred over atenolol for LV-mass regression in elderly hypertension; extends evidence on class-specific effects on hypertrophy.

Structured PICO

Does verapamil reduce left ventricular mass compared to atenolol in elderly patients with hypertension?

P
Population
42 elderly patients with hypertension and mild ventricular hypertrophy
I
Intervention
Verapamil for six months
C
Comparator
Atenolol for six months (with chlorthalidone added more frequently to achieve blood-pressure reduction)
O
Outcome
Left-ventricular-mass indexsurrogate

In elderly hypertensive patients, verapamil effectively reduces left ventricular mass and improves diastolic filling without impairing systolic function, unlike atenolol.

Cite This Study

Schulman et al. (1990) studied this question.

synapsesocial.com/papers/6a6ff53ce5469ee92be0c0b8https://doi.org/10.1056/nejm199005103221904

Topics

Hypertension managementEchocardiography
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Factors Influencing Cardiac Hypertrophy in Hypertensive Patients1981 · 45 citations
  2. 2Reversal of Left Ventricular Hypertrophy after Treatment of Hypertension by Atenolol for One Year1982 · 26 citations
  3. 3A comparison of verapamil and propranolol for the initial treatment of hypertension. Racial differences in response1986 · 95 citations
  4. 4Cardiac pumping ability following reversal of hypertrophy and hypertension in spontaneously hypertensive rats.1980 · 58 citations
  5. 5Prolonged contraction duration in aged myocardium.1975 · 200 citations