FKBP12.6 binds RyR2 with high affinity and inhibits basal activity, but this interaction is not altered by PKA-dependent phosphorylation, challenging previous models of RyR2 regulation.
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Challenges prior PKA-RyR2 dissociation models; leaves open relevance to human HF or intact myocytes.
Guo et al. (2010) studied this question.
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