February 21, 2012PLoS ONEOpen Access

FKBP12 Activates the Cardiac Ryanodine Receptor Ca2+-Release Channel and Is Antagonised by FKBP12.6

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Population

Single sheep RyR2 channels incorporated into planar phospholipid bilayers and rat isolated permeabilised…

Design

Preclinical

Authors

EGElena GalfrèUniversity of Modena and Reggio Emilia SPSamantha J. PittSt. Andrews University EVElisa VenturiUniversität Innsbruck

Discussion

Member takes

Implication

May promote RyR2-mediated arrhythmias in heart failure; hypothesis-generating and requires in vivo validation.

Structured PICO

Population

Single sheep RyR2 channels incorporated into planar phospholipid bilayers and rat isolated permeabilised cardiac cells

Intervention

FKBP12 and FKBP12.6

Outcome

RyR2 channel gating and spontaneous waves of Ca(2+)-induced Ca(2+)-release (Ca2+ wave frequency and SR Ca2+ content)surrogate

FKBP12 is a high-affinity activator of cardiac RyR2 channels that is antagonized by FKBP12.6, suggesting that alterations in their relative concentrations may contribute to 'leaky' RyR2 channels and arrhythmias in heart failure.

Cite This Study

Galfrè et al. (2012) studied this question.

synapsesocial.com/papers/6a7050caac440176ef28fa10 https://doi.org/10.1371/journal.pone.0031956

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FKBP12 Activates the Cardiac Ryanodine Receptor Ca2+-Release Channel and Is Antagonised by FKBP12.6

Discussion

Member takes

Implication

Structured PICO

Cite This Study

FKBP12 Activates the Cardiac Ryanodine Receptor Ca2+-Release Channel and Is Antagonised by FKBP12.6

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider