Why the study?
Does sodium bicarbonate infusion reduce ergoreflex overactivation in patients with chronic heart failure?
Population
10 stable chronic heart failure patients and 10 age- and sex-matched healthy subjects.
Comparison
Infusions of insulin, sodium nitroprusside… vs Saline infusion and healthy control subjects.
Design
Other
Authors
Loading...
May support targeting H+ in CHF exertional dyspnea; leaves open whether bicarbonate improves symptoms or exercise capacity.
Does sodium bicarbonate infusion reduce ergoreflex overactivation in patients with chronic heart failure?
Reduction of H+ concentration by sodium bicarbonate infusion abolishes increased ergoreceptor activity in chronic heart failure, highlighting the role of H+ in exertion intolerance.
Scott et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: