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October 1, 1995The Journal of Cell BiologyOpen Access

Myosin is involved in postmitotic cell spreading.

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Population

Potoroo tridactylis kidney (PtK2) cells

Design

Preclinical

Authors

LCLouise P. CramerMRC Laboratory for Molecular Cell Biology
Timothy J. Mitchison
Timothy J. MitchisonUniversity of Vermont

Discussion

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Implication

No direct clinical implications in cardiology; leaves open myosin II as a target in cardiovascular cell models.

Structured PICO

P
Population
Potoroo tridactylis kidney (PtK2) cells
I
Intervention
Butanedione monoxime (BDM)
O
Outcome
Postmitotic cell spreadingsurrogate

This basic science study demonstrates that myosin, likely myosin II, is involved in postmitotic cell spreading.

Cite This Study

Cramer et al. (1995) studied this question.

synapsesocial.com/papers/6a6ffbde8031ec7bb1dc0cabhttps://doi.org/10.1083/jcb.131.1.179
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exchange of actin subunits at the leading edge of living fibroblasts: possible role of treadmilling.1985 · 640 citations
  2. 2Isolation and Characterization of Myosin and Two Myosin Fragments from Human Blood Platelets1971 · 132 citations
  3. 3Brain myosin-V is a two-headed unconventional myosin with motor activity1993 · 437 citations
  4. 4Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth cone.1988 · 860 citations
  5. 5Organization of actin in the leading edge of cultured cells: influence of osmium tetroxide and dehydration on the ultrastructure of actin meshworks.1981 · 342 citations