Population
Mouse and human sera; PF4-knockout mice
Comparison
rAAV-8 and rAAV-9 vectors vs Wild-type mice
Design
Preclinical
Authors
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Species differences in rAAV–blood protein binding may alter transduction; leaves open vector optimization for human trials.
The impact of serum proteins on the transduction properties of rAAV-8 and rAAV-9 is similar between mouse and human sera, supporting the translation of mouse model findings to human preclinical trials.
Denard et al. (2018) studied this question.
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