January 1, 2002Journal of Biological ChemistryOpen Access

A Phosphatidylinositol 3-Kinase-independent Insulin Signaling Pathway to N-WASP/Arp2/3/F-actin Required for GLUT4 Glucose Transporter Recycling

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Population

Cultured adipocytes

Design

Preclinical

Authors

ZJZhen JiangFujian Medical University ACAnil ChawlaUniversity of Massachusetts Chan Medical School ABAvirup BoseNovartis (Switzerland)

Discussion

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Implication

Extends mechanistic insight into GLUT4 regulation in animals; human relevance and clinical translation remain open.

Structured PICO

Population

Cultured adipocytes

Intervention

Insulin stimulation, expression of dominant inhibitory N-WASP-DeltaWA protein, inhibitory TC10 (T31N) mutant, and wortmannin

Outcome

Cortical localization of N-WASP and Arp3, cortical F-actin polymerization, and GLUT4 translocationsurrogate

N-WASP functions downstream of TC10 in a PI 3-kinase-independent insulin signaling pathway to mobilize cortical F-actin, promoting GLUT4 responsiveness to insulin.

Cite This Study

Jiang et al. (2002) studied this question.

synapsesocial.com/papers/6a6ffc6af44fa9f079dd807d https://doi.org/10.1074/jbc.m108280200

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A Phosphatidylinositol 3-Kinase-independent Insulin Signaling Pathway to N-WASP/Arp2/3/F-actin Required for GLUT4 Glucose Transporter Recycling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A Phosphatidylinositol 3-Kinase-independent Insulin Signaling Pathway to N-WASP/Arp2/3/F-actin Required for GLUT4 Glucose Transporter Recycling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider