November 18, 2003Molecular Endocrinology
Skeletal Muscle Cells and Adipocytes Differ in Their Reliance on TC10 and Rac for Insulin-Induced Actin Remodeling
Population
Skeletal muscle cells (myoblasts and differentiated myotubes) and adipocytes
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Muscle insulin signaling differs from adipocytes; leaves open muscle-specific Rac mechanisms and cautions against cross-cell-type extrapolation.
Structured PICO
P
Population
Skeletal muscle cells (myoblasts and differentiated myotubes) and adipocytes
I
Intervention
Insulin stimulation and transfection with dominant-negative TC10 alpha mutants
O
Outcome
Actin remodeling and GLUT4 translocation to the cell surfacesurrogate
Insulin-induced actin remodeling and GLUT4 translocation rely on different signaling pathways in skeletal muscle cells compared to adipocytes, with myocytes lacking a functional TC10-dependent pathway.
Cite This Study
JeBailey et al. (2003) studied this question.