November 19, 2010Nephrology Dialysis TransplantationOpen Access

Kidney transplantation improves arterial function measured by pulse wave analysis and endothelium-independent dilatation in uraemic patients despite deterioration of glucose metabolism

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Why the study?

Does kidney transplantation improve arterial function in uraemic patients?

Population

80 uraemic patients, comprising 40 kidney recipients and 40 patients without known diabetes remaining on the…

Comparison

Kidney transplantation vs Remaining on the waiting list for kidney…

Design

Cohort

Follow-up

12 months

Authors

MHMads HornumUniversity of Copenhagen PCPer Axel ClausenNational Research Centre for the Working Environment TIThomas IdornNovo Nordisk (Denmark)

Discussion

Member takes

Implication

May support transplant consideration for arterial benefits in uraemia; hypothesis-generating and requires RCTs before practice change.

Structured PICO

Does kidney transplantation improve arterial function in uraemic patients?

Population

80 uraemic patients, comprising 40 kidney recipients (Tx group, age 38 ± 13 years) and 40 patients without known diabetes remaining on the waiting list for kidney transplantation (uraemic control group, age 47 ± 11 years).

Intervention

Kidney transplantation

Comparator

Remaining on the waiting list for kidney transplantation (uraemic control group)

Outcome

Arterial function estimated by pulse wave velocity (PWV) of the carotid-femoral pulse wave, aortic augmentation index (AIX), flow-mediated (FMD) and nitroglycerin-induced vasodilatation (NID) of the brachial artery at 12 monthssurrogate

Kidney transplantation significantly improves arterial function and lowers blood pressure at 1 year despite a deterioration in insulin sensitivity.

Cite This Study

Hornum et al. (2010) studied this question.

synapsesocial.com/papers/6a6ffca475498292b7095e56 https://doi.org/10.1093/ndt/gfq704

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Kidney transplantation improves arterial function measured by pulse wave analysis and endothelium-independent dilatation in uraemic patients despite deterioration of glucose metabolism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Kidney transplantation improves arterial function measured by pulse wave analysis and endothelium-independent dilatation in uraemic patients despite deterioration of glucose metabolism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider