Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 1, 2003Transplantation

Successful renal transplantation decreases aortic stiffness and increases vascular reactivity in dialysis patients

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does successful renal transplantation improve aortic stiffness and vascular reactivity in hemodialysis patients?

Population

41 hemodialysis patients and 20 essential hypertension controls. A subgroup of 20 HD patients received…

Comparison

Live-related renal transplantation vs Pre-transplantation state and essential…

Design

Cohort

Follow-up

3 months after transplantation

Authors

ACAdrian CovicThe George Institute for Global HealthDGDavid GoldsmithEmory UniversityPGPaul Gusbeth–TatomirFresenius Medical Care (Germany)

Discussion

Loading...

Member takes

Overview

May improve vascular stiffness after renal transplant in ESRD; hypothesis-generating and requires RCTs before changing practice.

Structured PICO

Does successful renal transplantation improve aortic stiffness and vascular reactivity in hemodialysis patients?

P
Population
41 hemodialysis (HD) patients (20 men; age 41.8 years) and 20 essential hypertension (HTA) controls (10 men; age 43.6 years). A subgroup of 20 HD patients (10 men; age 39.7 years) received live-related renal transplants.
I
Intervention
Live-related renal transplantation
C
Comparator
Pre-transplantation state (on hemodialysis) and essential hypertension controls
O
Outcome
Aortic stiffness measured by aortic pulse wave velocity (PWV) and augmentation index (AGI)surrogate

Successful renal transplantation in hemodialysis patients significantly improves aortic stiffness and vascular reactivity to levels comparable to patients with essential hypertension.

Cite This Study

Covic et al. (2003) studied this question.

synapsesocial.com/papers/6a72f78564f3cafe06cf2c36https://doi.org/10.1097/01.tp.0000086343.32903.a8
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Influence of Dialytic Modality on Arterial Stiffness, Pulse Wave Reflections, and Vasomotor Function2004 · 39 citations
  2. 2Comparative effects of renal transplantation and maintenance dialysis on arterial stiffness and left ventricular mass index2008 · 19 citations
  3. 3Influence of Renal Transplantation and Living Kidney Donation on Large Artery Stiffness and Peripheral Vascular Resistance2019 · 15 citations
  4. 4Changes in endothelial function before and after renal transplantation*2006 · 31 citations
  5. 5Improved Arterial Stiffness Indices 3 and 6 Months after Living-donor Renal Transplantation2023 · 2 citations