Key result
Living-donor renal transplantation significantly reduced the augmentation index from 21.53% pre-transplant to 16.19% at 6 months post-transplant (P<0.05).
Why the study?
Arterial stiffness is a non-traditional cardiovascular risk factor in chronic kidney disease, and successful renal transplantation may restore renal function and improve metabolic abnormalities involved in arterial stiffness.
Does living-donor renal transplantation improve arterial stiffness indices in patients with end-stage kidney disease?
Population
26 ESKD patients scheduled for living-donor renal transplantation
Comparison
Post-transplantation (3 and 6 months) vs pre-transplantation baseline
Design
Prospective study
Follow-up
6 months
Authors
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AI reduction after living-donor RT may lower CV risk in ESKD; leaves open PWV effects and immunosuppression impact for prospective trials.
Cohort (n=26)
Does living-donor renal transplantation improve arterial stiffness indices in patients with end-stage kidney disease?
Absolute Event Rate: 16.19% vs 21.53%
p-value: p=<0.05
Successful living-donor renal transplantation significantly improves arterial stiffness (augmentation index) at 6 months, potentially reducing cardiovascular risk in ESKD patients.
Singh et al. (2023) conducted a cohort in End-stage kidney disease (ESKD) (n=26). Living-donor renal transplantation vs. Pre-transplant baseline was evaluated on Augmentation index (AI) (p=<0.05). Living-donor renal transplantation significantly reduced the augmentation index from 21.53% pre-transplant to 16.19% at 6 months post-transplant (P<0.05).
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