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February 12, 2008Clinical Transplantation

Comparative effects of renal transplantation and maintenance dialysis on arterial stiffness and left ventricular mass index

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Why the study?

Does renal transplantation improve arterial stiffness and left ventricular mass index compared to maintenance hemodialysis?

Population

71 subjects including 28 renal transplantation patients, 23 hemodialysis patients, and 20 healthy subjects

Comparison

Renal transplantation vs Maintenance hemodialysis

Design

Cohort

Follow-up

1 year

Authors

KKKenan KevenAnkara UniversityRCReyhan CalayoğluŞŞŞule ŞengülAnkara University

Discussion

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Implication

May favor RTx over HD for arterial stiffness reduction; leaves open LVMi effects and needs prospective trials.

Structured PICO

Does renal transplantation improve arterial stiffness and left ventricular mass index compared to maintenance hemodialysis?

P
Population
71 subjects including 28 renal transplantation (RTx) patients, 23 hemodialysis (HD) patients, and 20 healthy subjects
I
Intervention
Renal transplantation
C
Comparator
Maintenance hemodialysis
O
Outcome
Changes in arterial stiffness (pulse wave velocity [PWV]) and left ventricular mass index (LVMi) at 1 yearsurrogate

Renal transplantation markedly improves arterial stiffness compared to maintenance hemodialysis at 1 year, though its impact on left ventricular mass index does not significantly differ from hemodialysis.

Cite This Study

Keven et al. (2008) studied this question.

synapsesocial.com/papers/6a6ffca475498292b7095e57https://doi.org/10.1111/j.1399-0012.2008.00794.x

Topics

Women and heart diseaseEchocardiography
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Left Ventricular Hypertrophy Is Associated with Arterial Stiffness and Vascular Calcification in Hemodialysis Patients2004 · 161 citations
  2. 2Pulse wave analysis to assess vascular compliance changes in stable renal transplant recipients2004 · 18 citations
  3. 3Vasoactive Drugs Influence Aortic Augmentation Index Independently of Pulse-Wave Velocity in Healthy Men2001 · 395 citations
  4. 4Successful renal transplantation decreases aortic stiffness and increases vascular reactivity in dialysis patients2003 · 107 citations
  5. 5Acute effect of haemodialysis on arterial stiffness: membrane bioincompatibility?2004 · 18 citations