Why the study?
Does IRF1 inhibit hepatitis E virus replication in cell culture models?
Does IRF1 inhibit hepatitis E virus replication in cell culture models?
IRF1 restricts hepatitis E virus replication by activating STAT1 to induce antiviral IFN-stimulated genes, independent of IFN production.
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IRF1 may represent a novel HEV therapeutic avenue; leaves open efficacy in clinical settings.
Xu et al. (2016) studied this question.
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