December 17, 2021The FASEB Journal

Hepatitis E virus‐encoded microRNA promotes viral replication by inhibiting type I interferon

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Why the study?

Hepatitis E virus is a predominant pathogen of acute hepatitis, but little is known about HEV-encoded miRNA (HEV-miR-A6).

Structured PICO

Population

In vitro and in vivo models of Hepatitis E virus infection (HEV-infected mice) and clinical samples from acute hepatitis E and convalescence patients.

Intervention

Over-expression of HEV-encoded microRNA (HEV-miR-A6) or its mutants

Comparator

Control or invalid mutant (HEV-miR-A6M2)

Outcome

Viral replication and type I interferon β (IFN-β) expressionsurrogate

HEV-miR-A6 promotes Hepatitis E viral replication by activating SIRP-α and inhibiting IFN-β expression.

Discussion

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Implication

HEV-miR-A6 identification may guide antiviral research; leaves open any clinical role in hepatitis E.

Cite This Study

A 2021 study studied this question.

synapsesocial.com/papers/6a8cfef009cefa1caaeaa3e3 https://doi.org/10.1096/fj.202101042r

View Full Paper

Ask AI

Bookmark

Hepatitis E virus‐encoded microRNA promotes viral replication by inhibiting type I interferon

Structured PICO

Discussion

Implication

Cite This Study

Hepatitis E virus‐encoded microRNA promotes viral replication by inhibiting type I interferon

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider