July 20, 2001Circulation ResearchOpen Access

High Glucose Impairs Voltage-Gated K + Channel Current in Rat Small Coronary Arteries

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Why the study?

Does high glucose impair voltage-gated K+ channel current in rat small coronary arteries?

Population

Small coronary arteries from Sprague-Dawley rats

Comparison

Incubation in high glucose for 24 hours vs Incubation in normal glucose or L-glucose for 24…

Design

Preclinical

Follow-up

24 hours

Authors

YLYanping LiuHainan Normal University KTKen TerataAkita University NRNancy J. RuschUniversity of Arkansas for Medical Sciences

Discussion

Member takes

Implication

May impair coronary vasodilation in hyperglycemia; hypothesis-generating for diabetic microvascular dysfunction in humans.

Structured PICO

Does high glucose impair voltage-gated K+ channel current in rat small coronary arteries?

Population

Small coronary arteries from Sprague-Dawley rats

Intervention

Incubation in high glucose (23 mmol/L D-glucose) for 24 hours

Comparator

Incubation in normal glucose (5.5 mmol/L D-glucose) or L-glucose (5.5 mmol/L D-glucose and 17 mmol/L L-glucose) for 24 hours

Outcome

Voltage-gated K+ (Kv) channel current density and superoxide productionsurrogate

Exposure to high glucose impairs voltage-gated K+ channel activity in coronary arteries via superoxide generation, providing a mechanism for reduced vasodilator responsiveness in hyperglycemia.

Cite This Study

Liu et al. (2001) studied this question.

synapsesocial.com/papers/6a6fffac6c240de38cdba5e9 https://doi.org/10.1161/hh1401.093294

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High Glucose Impairs Voltage-Gated K + Channel Current in Rat Small Coronary Arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

High Glucose Impairs Voltage-Gated K + Channel Current in Rat Small Coronary Arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider