Why the study?
The role of TonEBP in systemic lupus erythematosus and lupus nephritis remained to be explored.
Myeloid TonEBP plays a critical role in the pathogenesis of SLE and lupus nephritis by modulating TLR signaling and macrophage function, making it a potential therapeutic target.
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Macrophage TonEBP may drive SLE and LN progression; hypothesis-generating for inhibition pending interventional trials.
Yoo et al. (2023) studied this question.
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