The targeting of drugs using polymeric microspheres

The use of polymeric microspheres for the targeting of drugs to specific sites in the body is discussed in terms of the physico‐chemical properties that influence the fate and deposition of colloidal particles following intravenous administration. These include particle size, surface charge and surface hydrophobicity. Adsorbed surface coatings and adsorbed blood components also play a significant role in determining the site and extent of deposition. Drug targeting via the intravenous route can be achieved in certain instances. However, following administration the major site of particle deposition for small particles is the liver. The use of monoclonal antibodies as a coating agent to increase site specificity is also considered.