Population
Washed canine, bovine, or human platelets
Comparison
Thrombin combined with divalent cations vs Thrombin alone
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether divalent cations are required for thrombin-mediated platelet responses in vivo.
Thrombin requires divalent cations such as calcium or magnesium to induce rapid platelet agglutination, a reaction that is highly temperature-dependent.
Shermer et al. (1961) studied this question.
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