Key result
PCC compares with plasma for emergent warfarin reversal in major bleeding.
Why the study?
This review aimed to compare the efficacy and adverse effects of prothrombin complex concentrate and plasma for the rapid correction of vitamin K antagonist-associated hemorrhagic emergencies.
Systematic Review
Answers are grounded in this paper and cite their sources.
Evidence synthesis lacks quantitative results; leaves open optimal reversal strategy for warfarin-associated major bleeding.
Learning Objective• To compare the efficacy and adverse effects of prothrombin complex concentrate and plasma for rapid correction of vitamin K antagonist-associated hemorrhagic emergency Clinical vignetteA 78-year-old female presents to the emergency department with brisk hematochezia, fatigue, and tachycardia.She is receiving chronic oral anticoagulant therapy with warfarin as thromboprophylaxis for a mechanical mitral valve.International normalized ratio (INR) is 4.2.Red blood cell transfusion is ordered, and 10 mg of intravenous vitamin K is given.You are asked whether plasma or prothrombin complex concentrate is more effective for emergent reversal of her warfarin-associated coagulopathy.
No takes yet. Share an insight, caveat, or question.
Siegal et al. (2015) conducted a systematic review in Warfarin-associated major bleeding. Prothrombin complex concentrate vs. Plasma was evaluated on Efficacy and adverse effects for rapid correction of vitamin K antagonist-associated hemorrhagic emergency. Prothrombin complex concentrate and plasma were compared for emergent reversal of warfarin-associated major bleeding, though no quantitative results were reported in the abstract.
Synapse has enriched 10 related papers. Consider them for comparative context: