September 20, 2010Journal of Cellular Physiology

Acetylcholine inhibits hypoxia‐induced tumor necrosis factor‐α production via regulation of MAPKs phosphorylation in cardiomyocytes

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Why the study?

Does acetylcholine inhibit hypoxia-induced TNF-alpha production and protect cardiomyocytes?

Population

Cardiomyocytes subjected to hypoxia

Comparison

Acetylcholine (ACh) treatment vs Hypoxia without ACh treatment

Design

Preclinical

Authors

DLDongling LiAsus (Taiwan)JLJinjun LiuXi'an Jiaotong University BLBing‐Hang LiuMolina Center for Energy and the Environment

Discussion

Member takes

Implication

Hypothesis-generating for M2-mediated cardioprotection in hypoxic cardiomyocytes; human translation requires prospective validation.

Structured PICO

Does acetylcholine inhibit hypoxia-induced TNF-alpha production and protect cardiomyocytes?

Population

Cardiomyocytes subjected to hypoxia

Intervention

Acetylcholine (ACh) treatment

Comparator

Hypoxia without ACh treatment

Outcome

TNF-alpha mRNA and protein expressionsurrogate

Acetylcholine mediates cardioprotection against hypoxic injury in cardiomyocytes by activating the M2 receptor, regulating MAPKs phosphorylation, and down-regulating TNF-alpha production.

Cite This Study

Li et al. (2010) studied this question.

synapsesocial.com/papers/6a70092135aa2c282ce15591 https://doi.org/10.1002/jcp.22424

Topics

Bremelanotide

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Acetylcholine inhibits hypoxia‐induced tumor necrosis factor‐α production via regulation of MAPKs phosphorylation in cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Acetylcholine inhibits hypoxia‐induced tumor necrosis factor‐α production via regulation of MAPKs phosphorylation in cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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