Why the study?
Does a high fat diet impact contractile function, survival, and mitochondrial function under pressure overload?
Does a high fat diet impact contractile function, survival, and mitochondrial function under pressure overload?
In models of pressure overload, a high fat diet preserves cardiac function but comes at the cost of impaired survival and mitochondrial function.
High-fat diet trade-offs in overload models warrant caution; leaves open translational relevance for human HF.
Background: High fat diet (HFD) induces insulin resistance and obesity, conditions associated with worse outcome in heart failure. However, high fat diet may also be protective in cardiac disease. We assessed the impact of HFD under pressure overload on contractile function, survival and mitochondrial function.
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Schwarzer et al. (2015) studied this question.
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